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Peptide Zone

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Mon 2 Nov 2026

Sun 1 Nov 2026

UrgentSAFNews

HHS peptide compounding policy splits pharmacists and pharmacologists

Pharmacists say the HHS policy offers a safer route than the gray market for six unapproved peptides. Pharmacologists say none has passed FDA testing, and it is unclear how long the policy lasts or whether outsourcing facilities are covered.

WASHINGTON · Everyday Health report carried by Yahoo News, 29 Oct 2026, citing the HHS enforcement discretion policy on 503A peptide compounding dated 28 Oct 2026

6

Sat 31 Oct 2026

RoutineSAFAnalysis

GLP 1 cold medicine advice flags NSAIDs and pill timing in flu season

A pharmacist and three physicians told Yahoo Health that people on GLP 1 drugs should rethink NSAIDs, sedating antihistamines and combination cold products. The FDA's Wegovy label ties most kidney injury reports to dehydration.

NEW YORK · Yahoo Health report, 30 Oct 2026; FDA Wegovy prescribing information, Aug 2025 revision

600+
RoutineSAFNews

Woman reports retatrutide liver failure after injecting an unapproved vial

A 32 year old Australian woman told ABC News she developed acute liver failure days after injecting a vial labelled retatrutide, an experimental drug the FDA says has not been found safe and effective for any condition.

NEW YORK · New York Post report citing ABC News Australia, 30 Oct 2026; FDA statement on unapproved GLP-1 drugs, updated 1 Oct 2026

about 1 month
RoutineINDNews

Shoppers coming off GLP 1 drift back to old baskets within a year NielsenIQ says

NielsenIQ says the grocery baskets of people who stop GLP 1 drugs largely revert to non-user patterns within six to 11 months. Hy-Vee is betting on a dietitian-backed course, while trials show most people regain weight after stopping.

UNITED STATES · Food Dive report by Peyton Bigora, 30 Oct 2026, citing NielsenIQ, Numerator and Hy-Vee CEO Jeremy Gosch; trial context from JAMA Internal Medicine (SURMOUNT-4 post hoc, Nov 2025)

6 to 11 months
UrgentINDNews

Indian drugmaker plans November semaglutide relaunch after API impurity halt

Dr Reddy's CFO says the company is counting on semaglutide and an abatacept biosimilar for its next growth phase. Supply stopped in July after an impurity in scale up API batches, and the new pen target is about half the old one.

HYDERABAD · Moneycontrol interview with CFO M.V. Narasimham, 25 Oct 2026; Dr Reddy's semaglutide update call transcript in SEC filing, 9 Jul 2026

6 to 7 million
RoutineINDNews

Samsung Biologics PolyPeptide offer advances as shareholders elect new board

PolyPeptide shareholders backed all board proposals, electing five directors and voting to remove transfer and voting limits. Each step depends on the Samsung Peptide AG tender offer, and the release gives no price or timing.

BAAR, SWITZERLAND · PolyPeptide Group AG media release on EGM results, distributed via EQS News, 26 Oct 2026

5 directors

Fri 30 Oct 2026

RoutineSAFNews

Doctor raises GLP 1 long term side effects as evidence on lasting gut symptoms stays thin

Physician Joseph Varon told The National News Desk that some patients have diarrhea years after stopping GLP 1 drugs. The report said causation was not shown, and the meaning of rodent thyroid tumor findings for people remains unknown.

UNITED STATES · The National News Desk interview with physician Joseph Varon, published by CBS12, 29 Oct 2026

2 to 3 years
UrgentINDNews

Lilly Q3 earnings top forecasts as Mounjaro and Zepbound sales climb

Eli Lilly's third quarter revenue rose 39% to $24.4 billion as Mounjaro and Zepbound sales grew faster than prices fell, and the company raised its 2026 revenue forecast for a third time. The figures come from a Dow Jones report.

INDIANAPOLIS · Dow Jones report on Lilly third quarter 2026 results, published on Morningstar, 29 Oct 2026

$24.4 billion
UrgentINDNews

Lilly Q3 earnings show tirzepatide volume outrunning price cuts

Eli Lilly sold 53% more medicine by volume in the third quarter while realized prices fell 15%, lifting revenue 39% to $24.4 billion. About $900 million came from one time items, and the higher 2026 forecast is the company's own.

INDIANAPOLIS · Eli Lilly third quarter 2026 earnings release and investor presentation, 29 Oct 2026

53%
RoutineSAFExplainer

GLP 1 thyroid cancer warning covers two rare conditions as pills change levothyroxine timing

UT Southwestern endocrinologist Jeffrey Zigman says the GLP 1 thyroid warning targets medullary thyroid carcinoma and MEN2, not common thyroid disease, and sets out how levothyroxine users can space doses around oral Wegovy and Foundayo.

DALLAS · UT Southwestern Medical Center expert article by endocrinologist Jeffrey Zigman, released via Newswise on 28 Oct 2026 and republished by News-Medical

30 minutes

Thu 29 Oct 2026

UrgentTRLNews

ASC30 diabetes trial lowers HbA1c against placebo in 12 week Phase 2 study

Ascletis Pharma says its oral small molecule GLP 1 drug ASC30 lowered HbA1c by up to 1.7 points more than placebo in a 13 week U.S. Phase 2 study of 100 adults with type 2 diabetes. The data come from a press release and have not been peer reviewed.

HONG KONG · Ascletis Pharma press release via PR Newswire, 28 Oct 2026; ClinicalTrials.gov record NCT07321678

1.7 points
RoutineINDAnalysis

Corxel SPAC deal splits obesity pills from stroke drug ahead of CX11 Phase 3

Corxel's merger with Amanat Acquisition Corp takes only its oral obesity candidates public, leaving stroke drug JX10 with a private parent. CX11 data so far come from company summaries without a placebo figure.

BERKELEY HEIGHTS, NJ · Corxel US and Amanat Acquisition Corp joint press release, 26 Oct 2026; BioPharma Dive interview with Corxel US CFO Kevin Xie, 26 Oct 2026

$377 million
UrgentREGNews

HHS peptide compounding policy lets pharmacies make BPC 157 and five other peptides

An interim HHS policy lets licensed pharmacies compound BPC 157, epitalon, KPV, MOTS c, Semax and TB 500 under ten conditions. None is FDA approved, FDA reviewers advised against listing them, and a final rule is still pending.

WASHINGTON · HHS Enforcement Discretion Policy Regarding 503A Compounding Using Certain Peptide Bulk Drug Substances, posted Oct 27 to 28, 2026

6 peptides
RoutineSAFNews

Peptides in the emergency department need clinician training says OMED speaker

An emergency physician told OMED that GLP 1 drugs drive most peptide visits but warned about melanotan and the BPC 157 and TB 500 stack. Some of his approval claims do not match current labels.

LAS VEGAS · OMED session by Kenneth L. Frye Jr., DO, Oct 22 to 25 2026, Las Vegas, as reported in a Healio interview, 28 Oct 2026

5 peptides

Wed 28 Oct 2026

FlashTRLNews

Retatrutide Ozempic trial shows bigger A1C drop and double the weight loss

Lilly says retatrutide cut A1C by 2.2 points and weight by up to 20.9% at 80 weeks in type 2 diabetes, against 1.8 points and 9.4% on Ozempic. More people stopped retatrutide for side effects, and the data are not yet peer reviewed.

INDIANAPOLIS · Eli Lilly press release on TRANSCEND-T2D-2 topline results, 28 Oct 2026

20.9% vs 9.4%
RoutineSAFAnalysis

GLP 1 NAION lawsuits move ahead as vision loss evidence stays split

Vision loss suits against Eli Lilly and Novo Nordisk are pooled in a Philadelphia federal court. Europe calls NAION a very rare semaglutide side effect, but one large U.S. study found no clear rise in risk.

PHILADELPHIA · MedShadow report, 28 Oct 2026, with EMA PRAC statement of 6 Jun 2025 and JAMA journal studies

1 in 10,000
UrgentREGNews

Awiqli approval for children rests on adult trials and an 18 patient study

The FDA cleared insulin icodec for children aged 10 and older with type 2 diabetes, the first once weekly insulin for this group. The decision rests on adult trials and an 18 patient blood level study, not a pediatric efficacy trial.

SILVER SPRING, MD · FDA Drugs news item, 23 Oct 2026, with Novo Nordisk release of the same day

18 patients
UrgentTRLNews

TRIUMPH OSA trials test retatrutide for sleep apnea with and without diabetes

Two Phase 3 trials in The New England Journal of Medicine found Lilly's experimental retatrutide cut breathing pauses in 691 adults with obstructive sleep apnea, with and without type 2 diabetes. The drug is unapproved and heart outcomes were not tested.

BOSTON · The New England Journal of Medicine, Grunstein et al, TRIUMPH 1 OSA and TRIUMPH 2 OSA, DOI 10.1056/NEJMoa2611477, October 2026

24.4
RoutineSAFAnalysis

GLP 1 Eating Disorder Screening Gains Backing as Binge Eating Evidence Stays Thin

A News-Medical research review says GLP 1 drugs show early but inconsistent signals in binge eating disorder, while a 45 member World Psychiatry panel backs screening every patient for eating disorders before treatment.

PUNE, INDIA · News-Medical research review, 26 Oct 2026; World Psychiatry Delphi consensus, Oct 2026; Eating and Weight Disorders meta-analysis, 2025

94.7%

Tue 27 Oct 2026

RoutineINDNews

Employer GLP 1 coverage for weight loss stalls at 18 percent in KFF survey

The 2026 KFF Employer Health Benefits Survey finds 18% of firms with 200 or more workers cover GLP 1 drugs for weight loss, flat on last year, while more covering firms now require lifestyle programs or counselling.

SAN FRANCISCO · KFF 2026 Employer Health Benefits Survey, published 22 Oct 2026; Business Group on Health survey as reported by SHRM, 25 May 2026

18%
RoutineREGNews

WADA 2027 Prohibited List keeps semaglutide and tirzepatide permitted for athletes

WADA left the status of GLP 1 drugs unchanged for 2027. Semaglutide and tirzepatide stay legal for athletes and on its Monitoring Program while two studies look at their effects in sport.

MONTREAL · WADA announcement of the 2027 Prohibited List (approved by the Executive Committee 10 Sep 2026), as republished by World Rugby, 6 Oct 2026

1 Jan 2027
UrgentSAFNews

Peptide injectors need needle programs and safety advice say Queensland researchers

University of Queensland researchers say people injecting online peptides rarely see themselves as drug injectors and miss basic safety advice. NSW Health has warned hospitals of rising presentations, and needle programs report demand far above their contracts.

BRISBANE · The Conversation commentary by Akrigg, Ferris, Cornell and Piatkowski (University of Queensland), 26 Oct 2026; NSW Health Safety Information 009/26, 15 Oct 2026

200+
RoutineTRLNews

Dong A ST presents topical icotrokinra data from early skin and animal tests

At AAPS PharmSci 360, Dong-A ST reported a skin formulation of the oral psoriasis peptide icotrokinra that reached skin tissue and reduced inflammation in an animal model. No figures or human data were released.

NEW ORLEANS · Dong-A ST poster at AAPS PharmSci 360 2026, reported by Korea Biomedical Review, 27 Oct 2026; Johnson & Johnson release on Icotyde approval, 18 Mar 2026

3 genes

Mon 26 Oct 2026

UrgentSAFNews

JAMA Viewpoint warns peptide compounding vote threatens the FDA approval system

Researchers at the Center for Science in the Public Interest say an FDA advisory committee vote backing six unapproved peptides, including BPC 157, for pharmacy compounding could undercut drug approval and put patients at risk.

WASHINGTON · JAMA Viewpoint by Samantaroy, Xu and Lurie (Center for Science in the Public Interest), published online 26 Oct 2026, doi 10.1001/jama.2026.19125

6 of 7
RoutineTRLNews

Elecoglipron kidney data from SOLSTICE support a 7000 patient phase 3 outcomes trial

At Kidney Week 2026, investigator Hiddo Heerspink said AstraZeneca's oral GLP 1 drug elecoglipron lowered urine albumin in a phase 2 diabetes trial. A phase 3 kidney outcomes trial with about 7,000 people is now recruiting.

DENVER · Pharmacy Times interview with Hiddo Heerspink on ASN Kidney Week 2026 data, 26 Oct 2026; ClinicalTrials.gov records NCT06579105 and NCT07753993

7,000
RoutineTRLNews

Tirzepatide real world data from England beat semaglutide on glucose and weight goals

A retrospective study presented at EASD 2026 found that 46.3% of adults with type 2 diabetes starting tirzepatide reached HbA1c below 6.5% at 12 months, against about one in five on semaglutide, GlobalData reported.

LONDON · GlobalData analysis of a real world study presented at the EASD 2026 Annual Meeting, 14 Oct 2026, reported by Longevity.Technology on 26 Oct 2026

46.3%
RoutineSAFNews

Tirzepatide suicidal ideation risk lower in adults with obesity and depression in records study

A Translational Psychiatry study of 24,103 matched pairs found adults with obesity and major depression who started tirzepatide had a lower recorded risk of suicidal ideation than those on other obesity drugs. The authors say it is not proof of a protective effect.

TAINAN · Translational Psychiatry, Liu, Chu et al., published 25 Oct 2026, doi 10.1038/s41398-026-04518-0

HR 0.63